This study is the first to provide a comprehensive speed of sound database for multi-component jet mixing at high pressure. It serves as a unique reference for numerical simulations of mixture preparation processes in future liquid rocket engines and internal combustion engines. We performed quantitative speed of sound measurements in jet mixing zones for five configurations with well-defined experimental conditions. The database covers three different injectant fluids (two alkanes and a fluoroketone) that were brought beyond their critical temperature and pressure prior to injection and discharged into cold nitrogen at supercritical pressure (with respect to the pure injectant properties). Here, we chose the conditions such that subsonic jets were obtained and re-condensation due to cooling of the injected fluid was prevented. Hence, we provide speed of sound data for single-phase jet mixing for three different binary systems. Quantitative data are presented along the jet centerline with sufficiently high spatial resolution to properly resolve the axial decay. In addition, two radial profiles at a position close to the nozzle allow for an assessment of the transversal mixing characteristics. The experimental speed of sound data show consistent trends, which corroborate that mixture effects are correctly resolved in the measurement.