Large-eddy simulation (LES) for momentum transport combined with the one-dimensional turbulence (ODT) model for momentum and reactive scalars' transport is designed to capture subgrid scale (SGS) turbulence-chemistry interactions. An extension of the original LES-ODT formulation is developed to capture these interactions in turbulent spatially-developing reacting shear layers. The LES-ODT results are compared to results from direct numerical simulations (DNS). Lewis number parametric variations for the variable-density simulations are carried out. The validation with DNS shows that the LES-ODT approach can qualitatively and quantitatively capture important salient features of turbulent shear layers statistics, including large-scale flow patterns, shear layer growth and mean and RMS statistics of velocity and reactive scalars. (C) 2018 Elsevier Ltd. All rights reserved.