The objective of this paper is to study the influence of wall properties and Cu-water nano fluid in a non-uniform inclined tube. In this analysis, two dimensional flow of a viscous nano fluid generated by peristaltic motion is observed, thermal and velocity slip effects are also taken into account. The features of peristaltic structures are determined by the dominance of viscous effects over inertial effects using the long wave length approximation. Exact solutions have been established for both velocity and temperature profiles, which include nanoparticle effects. Graphical results are also obtained for both velocity, temperature profile and trapping phenomena is also discussed. Temperature profile decreases by increasing values of nanoparticle volume fraction. This justifies the use of the nanoparticle in different type as a coolant. (C) 2018 Published by Elsevier Ltd.