This work is to research the influence of different solvent properties and the composition on the solubility of iopromide. The solubility values of iopromide in some pure and binary solvent mixtures have been measured from T = 273.15 to 318.15 K. The result showed that the solubility obtained a maximum value in mole fraction (x = 55.426 x 10(-4) at T = 318.15 K) in pure N,N-dimethylformamide (DMF) and the minimum data (x = 9.9 x 10(-6) at T = 273.15 K) in neat toluene. The values in pure solvents obeyed the following order: DMF > methanol > ethanol > isopropyl alcohol > acetone > ethyl acetate > toluene. In mixed solvents, it was increased with increasing mass fraction of DMF at a given temperature. Moreover, the obtained solubility data in pure solvents were correlated with the modified Apelblat equation, and three cosolvent models (the Jouyban-Acree model, the Apelblat-Jouyban-Acree model, and CNIBS/R-K model) were applied to correlate solubility in the binary mixture. The maximum values of relative average deviation for back-calculation of iopromide in studied mixtures varied from 0.08 to 4.52%. Correlation coefficient values all approximately equal 1, which indicates that these models were very consistent with the experimental values. Furthermore, the results of powder X-ray diffraction indicate that there is no polymorph transformation or solvate formation during the solubility determination.