Vapor-liquid equilibrium (VLE) data for the binary system of acetone (1) + hexamethyl disiloxane (HMDSO, 2) and the ternary system of acetone (1) + HMDSO (2) + ethyl acetate (EAC, 3) were obtained at 101.3 kPa. The acetone (1) + HMDSO (2) mixture had azeotropic temperature of 329.00 K, x(1,az) = 0.9661. The binary VLE values and ternary VLE values were confirmed to be thermodynamically consistent using the Herington method and the McDermott-Ellis method, respectively. The binary VLE data were correlated using the nonrandom two-liquid (NRTL), universal quasichemical activity coefficient (UNIQUAC), and Wilson models, and the NRTL model has the best correlation with the experimental data. Furthermore, the acetone (1) + HMDSO (2) + EAC (3) ternary VLE data were predicted with the NRTL model using the binary interaction parameter obtained by association of the contained binary system, and the calculated data were in good agreement with the ternary experimental data. To further describe the ternary system, the residue curves were provided by Aspen Plus using the NRTL model.