Poly(ether sulfone) (PES)/poly(vinyl pyrrolidone) (PVP) blend heterogeneous cation exchange membranes were prepared by solution casting technique using dimethylformamide as solvent and cation exchange resin powder as functional groups agent. In this study, Taguchi experiment design method was employed for investigating the effects of controlling variables including polymer binder (PVP + PES) to total casting solution ratio, blend ratio of polymer binders (PVP to PES), resin to polymer binder ratio, and casting temperature on electrochemical characteristics of PES/PVP heterogeneous membranes. To this aim, each factor was considered at 4 different levels and therefore, 16 experiments were designed. To improve the quality of the membranes ultrasonic was used for appropriate dispersing of resin particles in the matrix of the membranes. According to the results, the averaged maximum values of 1.535 meq/g and 46.6 mV were obtained for IEC and membrane potential, respectively. Also, the highest obtained value of ion permeability tests was equal to 1.33 m/s. Finally, the synthesis conditions was optimized by considering the IEC and membrane potential as the objective functions which gave the values of 1.55 meq/g and 1.39 m/s for IEC and membrane potential, respectively, which proved that the synthesized membrane can be considered as a promising heterogeneous membrane. (C) 2018 Elsevier Inc. All rights reserved.