MIL-125(Ti)-NH2 has been modified by reaction of salicylaldehyde with the terephthalate amino groups to form a salicylideneimine that act as ligand of Cu2+. The success of the postsynthetic modification was assessed by FTIR spectroscopy of the MIL-125(Ti)-NH2-Sal-Cu and by analysis by H-1 NMR spectroscopy of the organic linkers upon dissolution of MIL-125(Ti)-NH2-Sal-Cu. In comparison with parent MIL-125(Ti)-NH2 and MIL-125(Ti)-NH2-Sal, that exhibit a poor activity, the presence of the Cu-Schiff base complex in MIL-125(Ti)-NH2-Sal-Cu catalyst for the oxidation of 1-phenylethanol by tert-butylhydroperoxyde (TBHP, 3 eq.) increases notably the catalytic activity. Hot filtration test and reusability experiments confirm that the process is heterogeneous and that MIL-125(Ti)-NH2-Sal-Cu is stable under the reaction conditions. Quenching studies and EPR spectra using N-(t)butylphenylnitrone indicate the generation of (BuOO)-Bu-t. and (BuO center dot)-Bu-t under the reaction conditions. The scope of MIL-125(Ti)-NH2-Sal-Cu as oxidation catalyst by (BuOOH)-Bu-t was studied for benzyl alcohol as well as alicyclic and aliphatic alcohols and ethylbenzene. (C) 2018 Elsevier Inc. All rights reserved.