A new nanocomposite, molybdenum copper selenide (MoCuSe) nanoparticles decorated with reduced graphene oxide (rGO), was successfully prepared by a facile hydrothermal method. The MoCuSe-rGO modified glassy carbon electrode (MoCuSe-rGO/GCE) was fabricated for the first time, which provided a large surface area and exhibited a rapid electron transport rate for the bisphenol A (BPA). The electrochemical behavior of BPA was investigated with various techniques and a new electroanalytical method was established with differential pulse voltammetry. Under optimum conditions, the proposed sensor showed an excellent electrochemical response to BPA with detection limit of 9.0 x 10(-10) mol L-1 and wider linear range of 3.0 x 10(-9) mol x 10(-4) mol L-1. Finally, the proposed method was applied to determine BPA in real samples with satisfactory results. This work might provide a new thought for the development of electrochemical sensors with hybrid materials.