The TiO2 and composite TiO2/zeolite catalysts were investigated in the photocatalytic oxidation of model volatile organic compounds. The photocatalytic experiments were performed in a batch reactor using an FTIR in situ method for the detailed analysis of the reaction components in the gas phase. The kinetic data for the TiO2 and composite TiO2/zeolite photocatalysts were compared. A focus on the analysis of the total hazard of gas mixture during the process by using the total hazard index, which includes the contribution of all the gas-phase components, was made. The effect of composite TiO2/zeolite photocatalyst on the total hazard during the photocatalytic oxidation of different VOCs is studied and discussed. The composite TiO2/zeolite photocatalyst allows for suppressing the secondary pollution with harmful intermediates formed during the process that increases the efficiency of air purification compared to TiO2 alone.