The present study concerns with investigation of the electrochemical activity of meropenem (MP) at ultra-trace graphite electrode (UTGE). The electrochemical measurements were performed in various buffer solutions in pH range (2.0-8.0). One irreversible anodic peak was observed in acidic medium. The effects of pH and scan rate on the peak current and potential were studied. The adsorption-controlled nature of MP peak was demonstrated. Therefore, it is directed to develop adsorptive stripping square wave voltammetric technique (AdS-SWV) for quantitative determination of MP in drug substance, pharmaceutical vials and in presence of interference substances. Under optimum experimental conditions, a linear dependence relationship was obtained over MP concentration range of 500.0-15000.0 nM. The limits of detection (LOD) and quantification (LOQ) were 160.0 and 470.0 nM respectively. Chemical safety is assessed at different aspects. Qualitative and quantitative metrics reveal excellent eco-friendly voltammetric method. In spite of high budget of UTGE; multiple merits of nano-sensitivity, selectivity, greenness evidence and high efficiency encourage wide application of our developed method in QC using UTGE in comparison to other chemically-modified electrodes. (c) 2018 The Electrochemical Society.