This study investigated the electrochemical degradation of N-nitrosodimethylamine (NDMA) using a Ti-based nano-electrode as the cathode and Ti/Pt, Ti/IrO2, and Ti/RuO2 electrodes as the anode, respectively. Efficient electrochemical removal of NDMA was achieved. By studying the effect of Cl- concentration, the reaction was found to follow a pseudo-first-order kinetic model. In addition, the factors influencing the removal of NDMA were optimized by response surface methodology. The Box-Behnken design was employed to develop mathematical models for removal of NDMA, which was considered to indicate a relatively high correlation between observed and predicted values. Furthermore, the cyclic voltammetric waves suggested that NDMA was removed via both oxidation and reduction. Chronoamperometry results showed that the Ti-based nano-electrode had a larger specific surface area and stronger electrochemical activity than pure Ti. Thus, the present electrochemical treatment is an effective method for the removal of NDMA from aqueous solutions. (C) 2018 The Electrochemical Society.