A reliable and simple hybrid electrode is fabricated using carboxylated MWCNTs and PdNTs for the simultaneous determination of Ascorbic acid (AA), Dopamine (DA) and Uric acid (UA). The carboxylated MWCNTs and PdNTs are naturally reduced by a unique method. Physical characterization of the modified electrode which is represented as rMWCNTs-PdNTs/Gr, was carried out with the help of X-ray diffraction and electrochemical impedance spectroscopy techniques. The electrochemical properties of the developed sensor toward the detection of AA, DA and UA was examined using cyclic voltammetry, differential pulse voltammetry and Chronoamperometry. The modified electrode exhibits high sensitivity and selectivity with separation of AA, DA and UA anodic peaks at 117.5, 139.2 and 316.7 mV respectively. The response time of AA, DA and UA was found to be 2 s, 2 s and 3 s respectively. The low detection limit was observed at 0.175 mu M for AA, 0.1802 mu M for DA and 0.0360 mu M for UA. The proposed electrode also shows stability and reproducibility. (C) 2018 The Electrochemical Society.