Nanomaterial-enabled sensors are being designed for high-efficiency, multiplex-functionality and high-flexibility sensing applications. Many existing nanosensors have the inherent capacity to achieve such goals; however, they require further development into consumer- and operator-friendly tools with the ability to detect analytes in previously inaccessible locations, as well as at a greater scale than heretofore possible. Here, I discuss how nanotechnology-enabled sensors have great, as yet unmet, promise to provide widespread and potentially low-cost monitoring of chemicals, microbes and other analytes in drinking water.