Amphiphilic graft copolymers with cleavable side chains exhibit many superiorities in some fields, such as the encapsulation, drug delivery and release, etc. In this study, we demonstrated a redox-responsive Pickering emulsion that was stabilized by sheddable polymeric micelles with many reversible S-S linkages at core-shell interfaces. The sheddable polymeric micelles were achieved by the self-assembly of amphiphilic polyurethane-gpoly (N,N-dimethyl acrylamide) (PU-g-PDMA) copolymers whose PDMA side chains were tethered on PU backbones by means of the reversible S-S linkages. Such PU-g-PDMA copolymers were synthesized via the combination of the polyaddition reaction with the reversible addition-fragmentation chain transfer (RAFT) polymerization reaction. The structure, molecular weight and molecular weight distribution of the polymers were characterized by H-1 NMR and GPC analysis. Emulsifying experiments indicated sheddable polymeric micelles possessed perfect emulsifying performances, and highly stable oil-in-water Pickering emulsion could be formed at a low content of emulsifiers. At the same time, the S-S reversible linkages retained at core-shell interfaces of polymeric micelles allowed hydrophilic PDMA shells to be detached through the thiol-disulfide exchange reaction under a reductive environment, which also allowed the resultant Pickering emulsions with redox-responsive demulsification.