Science, Vol.361, No.6403, 661-+, 2018
Shifting the limits in wheat research and breeding using a fully annotated reference genome
Appels R ,
Eversole K ,
Feuillet C ,
Keller B ,
Rogers J ,
Stein N ,
Pozniak CJ ,
Stein N ,
Choulet F ,
Distelfeld A ,
Eversole K ,
Poland J ,
Rogers J ,
Ronen G ,
Sharpe AG ,
Pozniak C ,
Ronen G ,
Stein N ,
Barad O ,
Baruch K ,
Choulet F ,
Keeble-Gagnere G ,
Mascher M ,
Sharpe AG ,
Ben-Zvi G ,
Josselin AA ,
Stein N ,
Mascher M ,
Himmelbach A ,
Choulet F ,
Keeble-Gagnere G ,
Mascher M ,
Rogers J ,
Balfourier F ,
Gutierrez-Gonzalez J ,
Hayden M ,
Josselin AA ,
Koh C ,
Muehlbauer G ,
Pasam RK ,
Paux E ,
Pozniak CJ ,
Rigault P ,
Sharpe AG ,
Tibbits J ,
Tiwari V ,
Choulet F ,
Keeble-Gagnere G ,
Mascher M ,
Josselin AA ,
Rogers J ,
Spannagl M ,
Choulet F ,
Lang D ,
Gundlach H ,
Haberer G ,
Keeble-Gagnere G ,
Mayer KFX ,
Ormanbekova D ,
Paux E ,
Prade V ,
Simkova H ,
Wicker T ,
Choulet F ,
Spannagl M ,
Swarbreck D ,
Rimbert H ,
Felder M ,
Guilhot N ,
Gundlach H ,
Haberer G ,
Kaithakottil G ,
Keilwagen J ,
Lang D ,
Leroy P ,
Lux T ,
Mayer KFX ,
Twardziok S ,
Venturini L ,
Appels R ,
Rimbert H ,
Choulet F ,
Juhasz A ,
Keeble-Gagnere G ,
Choulet F ,
Spannagl M ,
Lang D ,
Abrouk M ,
Haberer G ,
Keeble-Gagnere G ,
Mayer KFX ,
Wicker T ,
Choulet F ,
Wicker T ,
Gundlach H ,
Lang D ,
Spannagl M ,
Lang D ,
Spannagl M ,
Appels R ,
Fischer I ,
Uauy C ,
Borrill P ,
Ramirez-Gonzalez RH ,
Appels R ,
Arnaud D ,
Chalabi S ,
Chalhoub B ,
Choulet F ,
Cory A ,
Datla R ,
Davey MW ,
Hayden M ,
Jacobs J ,
Lang D ,
Robinson SJ ,
Spannagl M ,
Steuernagel B ,
Tibbits J ,
Tiwari V ,
van Ex F ,
Wulff BBH ,
Pozniak CJ ,
Robinson SJ ,
Sharpe AG ,
Cory A ,
Benhamed M ,
Paux E ,
Bendahmane A ,
Concia L ,
Latrasse D ,
Rogers J ,
Jacobs J ,
Alaux M ,
Appels R ,
Bartos J ,
Bellec A ,
Berges H ,
Dolezel J ,
Feuillet C ,
Frenkel Z ,
Gill B ,
Korol A ,
Letellier T ,
Olsen OA ,
Simkova H ,
Singh K ,
Valarik M ,
van der Vossen E ,
Vautrin S ,
Weining S ,
Korol A ,
Frenkel Z ,
Fahima T ,
Glikson V ,
Raats D ,
Rogers J ,
Tiwari V ,
Gill B ,
Paux E ,
Poland J ,
Dolezel J ,
Cihalikova J ,
Simkova H ,
Toegelova H ,
Vrana J ,
Sourdille P ,
Darrier B ,
Appels R ,
Spannagl M ,
Lang D ,
Fischer I ,
Ormanbekova D ,
Prade V ,
Barabaschi D ,
Cattivelli L ,
Hernandez P ,
Galvez S ,
Budak H ,
Steuernagel B ,
Jones JDG ,
Witek K ,
Wulff BBH ,
Yu GT ,
Small I ,
Melonek J ,
Zhou RN ,
Juhasz A ,
Belova T ,
Appels R ,
Olsen OA ,
Kanyuka K ,
King R ,
Nilsen K ,
Walkowiak S ,
Pozniak CJ ,
Cuthbert R ,
Datla R ,
Knox R ,
Wiebe K ,
Xiang DQ ,
Rohde A ,
Golds T ,
Dolezel J ,
Cizkova J ,
Tibbits J ,
Budak H ,
Akpinar BA ,
Biyiklioglu S ,
Muehlbauer G ,
Poland J ,
Gao LL ,
Gutierrez-Gonzalez J ,
N'Daiye A ,
Dolezel J ,
Simkova H ,
Cihalikova J ,
Kubalakova M ,
Safar J ,
Vrana J ,
Berges H ,
Bellec A ,
Vautrin S ,
Alaux M ,
Alfama F ,
Adam-Blondon AF ,
Flores R ,
Guerche C ,
Letellier T ,
Loaec M ,
Quesneville H ,
Pozniak CJ ,
Sharpe AG ,
Walkowiak S ,
Budak H ,
Condie J ,
Ens J ,
Koh C ,
Maclachlan R ,
Tan YF ,
Wicker T ,
Choulet F ,
Paux E ,
Alberti A ,
Aury JM ,
Balfourier F ,
Barbe V ,
Couloux A ,
Cruaud C ,
Labadie K ,
Mangenot S ,
Wincker P ,
Gill B ,
Kaur G ,
Luo MC ,
Sehgal S ,
Singh K ,
Chhuneja P ,
Gupta OP ,
Jindal S ,
Kaur P ,
Malik P ,
Sharma P ,
Yadav B ,
Singh NK ,
Khurana J ,
Chaudhary C ,
Khurana P ,
Kumar V ,
Mahato A ,
Mathur S ,
Sevanthi A ,
Sharma N ,
Tomar RS ,
Rogers J ,
Jacobs J ,
Alaux M ,
Bellec A ,
Berges H ,
Dolezel J ,
Feuillet C ,
Frenkel Z ,
Gill B ,
Korol A ,
van der Vossen E ,
Vautrin S ,
Gill B ,
Kaur G ,
Luo MC ,
Sehgal S ,
Bartos J ,
Holusova K ,
Plihal O ,
Clark MD ,
Heavens D ,
Kettleborough G ,
Wright J ,
Valarik M ,
Abrouk M ,
Balcarkova B ,
Holusova K ,
Hu YQ ,
Luo MC ,
Salina E ,
Ravin N ,
Skryabin K ,
Beletsky A ,
Kadnikov V ,
Mardanov A ,
Nesterov M ,
Rakitin A ,
Sergeeva E ,
Handa H ,
Kanamori H ,
Katagiri S ,
Kobayashi F ,
Nasuda S ,
Tanaka T ,
Wu JZ ,
Appels R ,
Hayden M ,
Keeble-Gagnere G ,
Rigault P ,
Tibbits J ,
Olsen OA ,
Belova T ,
Cattonaro F ,
Jiumeng M ,
Kugler K ,
Mayer KFX ,
Pfeifer M ,
Sandve S ,
Xun X ,
Zhan BJ ,
Simkova H ,
Abrouk M ,
Batley J ,
Bayer PE ,
Edwards D ,
Hayashi S ,
Toegelova H ,
Tulpova Z ,
Visendi P ,
Song WN ,
Cui LC ,
Du XH ,
Feng KW ,
Nie XJ ,
Tong W ,
Wang L ,
Borrill P ,
Gundlach H ,
Galvez S ,
Kaithakottil G ,
Lang D ,
Lux T ,
Mascher M ,
Ormanbekova D ,
Prade V ,
Ramirez-Gonzalez RH ,
Spannagl M ,
Stein N ,
Uauy C ,
Venturini L ,
Stein N ,
Appels R ,
Eversole K ,
Rogers J ,
Borrill P ,
Cattivelli L ,
Choulet F ,
Hernandez P ,
Kanyuka K ,
Lang D ,
Mascher M ,
Nilsen K ,
Paux E ,
Pozniak CJ ,
Ramirez-Gonzalez RH ,
Simkova H ,
Small I ,
Spannagl M ,
Swarbreck D ,
Uauy C
An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue-and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
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