Melon seed oil has been extracted by Soxhlet (hexane) and by supercritical CO2 operating to various pressures and temperatures. Linoleic acid (67.06-68.22%) was the most abundant followed by oleic acid (21.63-22.45%), palmitic acid (5.57-6.23%) and stearic acid (2.98-3.67%). The highest inhibition of inflammation was 18.8% at 50 mu g/mL for hexane and SC-CO2 extracts obtained under 55 MPa and 70 degrees C. The largest inhibition of IGROV and OVAR tumor cell lines were 29.9% and 21.6%, respectively, at 50 mu g/mL for the ethanol extract. These results of biological activities indicate that melon seed oils can be dedicated to nutrition.