Modified simulated moving bed chromatography with two pumps for sugar separation

Jae-Ryong Song; Hyukmin Park; Jin-Il Kim; Ngoc Lan Mai; Yoon-Mo Koo

Korean Journal of Chemical Engineering, Vol.36, No.1, 109-114, January, 2019

DOI10.1007/s11814-018-0175-9 Export Citation

Modified simulated moving bed chromatography with two pumps for sugar separation

Jae-Ryong Song, Hyukmin Park, Jin-Il Kim, Ngoc Lan Mai, and Yoon-Mo Koo^†

Department of Biological Engineering, Inha University, Inchon 22112, Korea

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A modified SMB system composed of two pumps was developed for the separation of L-ribose and Larabinose from its binary mixture. In two-pump SMB operation, the flow rates required for separation in every column zones and product ports are identical to those in conventional SMB equipped with four pumps and are controlled by appropriate operation of valves during a cycle of switching time. The purity, yield and enrichment of sugars obtained by two-pump SMB separation were comparable to that of conventional SMB. The two-pump SMB system is therefore considered to be more economically efficient than conventional SMB by reducing the cost for SMB installation and pump operation.

Keywords:Two-pump;SMB;Chromatography;Sugar Separation;Energy Efficient

[References]

Broughton DB, Gerhold CG, Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets, U.S. Patent 2,985,589 (1961).
Juza M, Mazzotti M, Morbidelli M, Trends Biotechnol., 18, 108 (2000)
Ludemann-Hombourger O, Nicoud RM, Bailly M, Sep. Sci. Technol., 35(12), 1829 (2000)
Schramm H, Kaspereit M, Kienle A, Seidel-Morgenstern A, J. Chromatogr., 1006, 77 (2003)
Bae YS, Lee CH, J. Chromatogr., 1122, 161 (2006)
Wankat PC, Ind. Eng. Chem. Res., 40(26), 6185 (2001)
Wankat PC, Kim JK, Abstr. Pap. Am. Chem. Soc., 225, U966 (2003)
Kim JK, Wankat PC, Ind. Eng. Chem. Res., 43(4), 1071 (2004)
Wang X, Ching CB, Chem. Eng. Sci., 60(5), 1337 (2005)
Xie Y, Chin CY, Phelps DSC, Lee CH, Lee KB, Mun S, Wang NHL, Ind. Eng. Chem. Res., 44(26), 9904 (2005)
Mun SY, J. Liq. Chromatogr. Relat. Technol., 31, 1231 (2008)
Mun S, Ind. Eng. Chem. Res., 49(19), 9258 (2010)
Mun S, J. Chromatogr., 1218, 8060 (2011)
Mun S, Process Biochem., 46(4), 977 (2011)
Wei F, Shen B, Chen MJ, Zhao YX, Ind. Eng. Chem. Res., 51(16), 5805 (2012)
Katti AM, Jagland P, Analusis, 26, 38 (1998)
Pynnonen B, J. Chromatogr., 827, 143 (1998)
Strube J, Haumreisser S, Schmidt-Traub H, Schulte M, Ditz R, Org. Process. Res. Dev., 2, 305 (1998)
Jupke A, Epping A, Schmidt-Traub H, J. Chromatogr., 944, 93 (2002)
Vanneste J, De Ron S, Vandecruys S, Soare SA, Darvishmanesh S, Van der Bruggen B, Sep. Purif. Technol., 80(3), 600 (2011)
Lisec O, Hugo P, Seidel-Morgenstern A, J. Chromatogr., 908, 19 (2001)
Van Deemter JJ, Zuiderweg FJ, Klinkenberg A, Chem. Eng. Sci., 5, 271 (1956)

[Referenced By]

[1] Broughton DB, Gerhold CG, Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets, U.S. Patent 2,985,589 (1961).

[2] Juza M, Mazzotti M, Morbidelli M, Trends Biotechnol., 18, 108 (2000)

[3] Ludemann-Hombourger O, Nicoud RM, Bailly M, Sep. Sci. Technol., 35(12), 1829 (2000)

[4] Schramm H, Kaspereit M, Kienle A, Seidel-Morgenstern A, J. Chromatogr., 1006, 77 (2003)

[5] Bae YS, Lee CH, J. Chromatogr., 1122, 161 (2006)

[6] Wankat PC, Ind. Eng. Chem. Res., 40(26), 6185 (2001)

[7] Wankat PC, Kim JK, Abstr. Pap. Am. Chem. Soc., 225, U966 (2003)

[8] Kim JK, Wankat PC, Ind. Eng. Chem. Res., 43(4), 1071 (2004)

[9] Wang X, Ching CB, Chem. Eng. Sci., 60(5), 1337 (2005)

[10] Xie Y, Chin CY, Phelps DSC, Lee CH, Lee KB, Mun S, Wang NHL, Ind. Eng. Chem. Res., 44(26), 9904 (2005)

[11] Mun SY, J. Liq. Chromatogr. Relat. Technol., 31, 1231 (2008)

[12] Mun S, Ind. Eng. Chem. Res., 49(19), 9258 (2010)

[13] Mun S, J. Chromatogr., 1218, 8060 (2011)

[14] Mun S, Process Biochem., 46(4), 977 (2011)

[15] Wei F, Shen B, Chen MJ, Zhao YX, Ind. Eng. Chem. Res., 51(16), 5805 (2012)

[16] Katti AM, Jagland P, Analusis, 26, 38 (1998)

[17] Pynnonen B, J. Chromatogr., 827, 143 (1998)

[18] Strube J, Haumreisser S, Schmidt-Traub H, Schulte M, Ditz R, Org. Process. Res. Dev., 2, 305 (1998)

[19] Jupke A, Epping A, Schmidt-Traub H, J. Chromatogr., 944, 93 (2002)

[20] Vanneste J, De Ron S, Vandecruys S, Soare SA, Darvishmanesh S, Van der Bruggen B, Sep. Purif. Technol., 80(3), 600 (2011)

[21] Lisec O, Hugo P, Seidel-Morgenstern A, J. Chromatogr., 908, 19 (2001)

[22] Van Deemter JJ, Zuiderweg FJ, Klinkenberg A, Chem. Eng. Sci., 5, 271 (1956)