Tridax Procumbens Extract Loaded Electrospun PCL Nanofibers: A Novel Wound Dressing Material

Mathiazhagan Suryamathi; Chidhambaram Ruba; Periasamy Viswanathamurthi; Velramar Balasubramanian; Pachiappan Perumal

Macromolecular Research, Vol.27, No.1, 55-60, January, 2019

DOI10.1007/s13233-019-7022-7 Export Citation

Tridax Procumbens Extract Loaded Electrospun PCL Nanofibers: A Novel Wound Dressing Material

Mathiazhagan Suryamathi, Chidhambaram Ruba, Periasamy Viswanathamurthi^†, Velramar Balasubramanian¹, and Pachiappan Perumal¹

Department of Chemistry, Periyar University, Salem 636011, India
¹Department of Biotechnology, Periyar University, Salem 636011, India

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To overcome the bacterial infection which may leads to strain the wounds progressively, wound healing medicinal plant was choosen to treat the infection caused by bacteria. Though the medicinal wound healing plants are resistant to bacteria, the bare plant extract may face poor contact with the wound. This necessitate for a carrier for the plant extract. Polycaprolactone (PCL) electrospun nanofibers have been selected as carrier in this work due to its beneficial surface property and biocompatibility. Extract from the medicinal plant Tridax procumbens was immobilized on PCL electrospun nanofibers. The PCL nanofiber and Tridax procumbens extract immobilized nanofibers were characterized by SEM, XRD and EDAX. The morphology, porosity, swelling and weight loss percentage of the electrospun nanofibers have been investigated. The Tridax procumbens-PCL nanofibers were analyzed for its anti-bacterial activity. The results of the work confess that the scaffolds act as an enhancer of wound healing and treating surfaces that contain pathogenic microorganisms especially in hospital environment.

Keywords:PCL electrospun nanofibers;Tridax procumbens;immobilization;wound dressing

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[Referenced By]

[1] Kuete V, Medicinal plant research in Africa., Pharmacology and Chemistry, Elsevier, Oxford, 2013.

[2] O'Neill J, Review on Antimicrobial Resistance, Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations (2014).

[3] Rios J, Recio M, J. Ethnopharmacol., 100, 80 (2005)

[4] Katiyar C, Gupta A, Kanjilal S, Katiyar S, AYU (An International Quarterly Journal of Reasearch in Ayurveda), 33, 10 (2012).

[5] Thakur R, Jain N, Pathak R, Sandhu SS, Evidence-Based Complementary and Alternative Medicine (eCAM), 2011, 1 (2011).

[6] Budovsky A, Yarmolinsky L, Ben-Shabat S, Wound Repair Regen., 23, 171 (2015)

[7] Ankita J, Jain A, Int. J. Pharm. Bio. Sci., 3, 1 (2012)

[8] Ahmadullah M, Nayar MP, Red data book of Indian Plants (Peninsular India): Botanical survey of India, Calcutta, 1999.

[9] “Tridax procumbens”. Natural Resources Conservation Service PLANTS Database. USDA. Retrieved 15 December (2015).

[10] Ali M, Ravinder E, Ramachandram R, Fitoterapia, 72, 313 (2001)

[11] Strbo N, Yin N, Stojadinovic O, Adv. Skin Wound Care, 3, 492 (2014)

[12] Yoo HS, Kim TG, Park TG, Adv. Drug Deliv. Rev., 61, 1033 (2009)

[13] Gao Y, Truong YB, Zhu Y, Kyratzis IL, J. Appl. Polym. Sci., 131 (2014)

[14] Alippilakkotte S, Kumar S, Sreejith L, Colloids Surf. A: Physicochem. Eng. Asp., 529, 771 (2017)

[15] Reneker DH, Chun I, Nanotechnology, 7, 216 (1996)

[16] Subbiah T, Bhat GS, Tock RW, Pararneswaran S, Ramkumar SS, J. Appl. Polym. Sci., 96(2), 557 (2005)

[17] Agarwal S, Wendorff JH, Greiner A, Polymer, 49(26), 5603 (2008)

[18] Braghirolli DI, Steffens D, Pranke P, Drug Discov. Today, 19, 743 (2014)

[19] Al-Youssef HM, Amina M, Hassan S, Amna T, Jeong JW, Nam KT, Kim HY, Macromol. Res., 21(6), 589 (2013)

[20] Yousefi I, Pakravan M, Rahimi H, Bahador A, Farshadzadeh Z, Haririan I, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 75, 433 (2017)

[21] Semnani D, Lattifi D, Amani M, Pourdeyhimi B, Merati A, J. Text. Inst., 96, 295 (2005)

[22] Matsumoto H, Tanioka A, Membranes, 1, 249 (2011)

[23] Han J, Chen TX, Branford-White CJ, Zhu LM, Int. J. Pharm., 382, 215 (2009)

[24] Razavi S, Karbasi S, Morshed M, Esfahani HZ, Golozar M, Vaezifar S, Cell J., 17, 429 (2015)

[25] Shelke NB, Lee P, Anderson M, Mistry N, Nagarale RK, Ma XM, Kumbar SG, Polym. Adv. Technol., 27, 42 (2016)

[26] Guadalupe E, Ramos D, Shelke NB, James R, Gibney C, Kumbar SG, J. Appl. Polym. Sci., 132, 41879 (2015)

[27] Shao S, Zhou S, Li L, Li J, Luo C, Wang J, Li X, Weng J, Biomaterials, 32, 2821 (2011)

[28] Peng H, Zhou S, Guo T, Li Y, Li X, Wang J, Weng J, Colloids Surf. B: Biointerfaces, 66, 206 (2008)

[29] Ghasemi-Mobarakeh L, Semnani D, Morshed M, J. Appl. Polym. Sci., 106(4), 2536 (2007)

[30] Al-Youssef HM, Amina M, Hassan S, Amna T, Jeong JW, Nam KT, Kim HY, Macromol. Res., 21(6), 589 (2013)

[31] Qian Y, Zhang Z, Zheng L, Song R, Zhao Y, J. Nanomater., 2014, 1 (2014)

[32] Kim JH, Lee H, Jatoi AW, Im SS, Lee JS, Kim IS, Mater. Lett., 181, 367 (2016)

[33] Kumar SS, John R, Narayanan GL, Int. J. Pharm. Sci. Res., 6, 3 (2015)