쉘락/젤라틴을 함유한 저자극 · 친환경 매니큐어의 개발

심하은; 노대영; 김지민; 김도연; 남명석; 김동욱; Haeun Shim; Daeyoung Noh; Jimin Kim; Doyeon Kim; Myungsuk Nam; Donguk Kim

Korean Chemical Engineering Research, Vol.57, No.1, 22-27, February, 2019

DOI10.9713/kcer.2019.57.1.22 Export Citation

쉘락/젤라틴을 함유한 저자극 · 친환경 매니큐어의 개발

Development of Low Irritative, Eco-friendly Nail Polish Including Shellac/gelatin

심하은, 노대영, 김지민, 김도연, 남명석¹, 김동욱^†

인제대학교 제약공학과, 50834 경상남도 김해시 인제로 197
¹문교화학, 50931 경상남도 김해시 김해대로2575번길 33

Haeun Shim, Daeyoung Noh, Jimin Kim, Doyeon Kim, Myungsuk Nam¹, and Donguk Kim^†

Department of Pharmaceutical Engineering, Inje University, 197, Inje-ro, Gimhae-si, Gyeongsangnam-do, 50834, Korea
¹Mungyo, 33, Gimhae-daero 2575 beon-gil, 33, Gimhae-daero 2575beon-gil, Gimhae-si, Gyeongsangnam-do, 50931, Korea

E-mail:

초록

매니큐어는 손톱을 아름답게 꾸미기 위해 사용하는 색조화장품이지만 그 구성성분은 유해성분이 상당히 포함되어 있다. 매니큐어는 일반적으로 피막형성제, 색소, 용제, 계면활성제 및 침전방지제 등으로 구성되어 있다. 본 연구에서는 유해성 성분을 저자극, 친환경적인 성분으로 대체하여 4종의 매니큐어를 제조하고, 매니큐어로서 효력 비교실험과 안전성 및 안정성 시험을 실시하였다. 효력비교실험에서 쉘락/젤라틴 매니큐어 조성물(No. 4)이 내수성 및 적당한 강도를 지니면서 건조시간이 2분 내외로 대조군(4분 내외)보다 우수하고 악취도 개선되어, 피막형성제로서 가장 우수한 특성을 보여주었다. 또한 쉘락/젤라틴 매니큐어 조성물의 세포독성시험 결과, 1,000 μg/mL 농도에서 70% 이상의 세포생 존율로 시판되고 있는 매니큐어(50% 세포생존율)보다 독성이 낮았다. 4주간 온도 안정성 시험에서 저온에서는 색상의 변화가 없었으나, 상온과 고온에서 외관상변화 및 점도변화가 관찰되어 추후 제형의 개선이 필요한 것으로 생각된다.

Nail polish is used to decorate nail beautifully however, it contains lots of toxic materials. Generally, Nail polish consists of film-forming agent, colorant, solvent, surfactant and stabilizer. In this study, to replace toxic chemicals to low irritative, eco-friendly ingredients, we prepared 4 kinds of nail polish and tested safety, stability and performance. Nail polish including shellac/gelatin showed best performance in water-resistance, friability and drying time. When cell toxicity test is done by MTT assay, shellac-gelatin nail polish showed over 70% cell viability at 1,000 μg/mL whereas control nail polish in market showed 50% cell viability. At 4 weeks temperature stability test, color was stable at low temperature however it needs formulation improvement at higher temperature.

Keywords:Nail polish;Shellac;Gelatin;Safety test;Stability test;Performance test

[References]

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Han DG, Noh DY, Shim HE, Jeong SH, ParK SH, Choi HS, Kim DU, Korean Chem. Eng. Res., 56(3), 309 (2018)
Booth DG, Dann SE, Weller MT, Dyes Pigment., 58, 73 (2003)
Allen NS, Polym. Degrad. Stabil., 44, 357 (1994)
Plesters J, Studies in Conservation, 11(2), 62 (1966)
Khairuddin, Pramono E, Utomo SB, Wulandari V, Zahrotul W, Clegg F, Materials Science and Engineering, 107, 01206 (2016)
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[1] Moossavi M, Scher RK, Clinics in Dermatology, 19(4), 445 (2001)

[2] Rieder EA, Tosti A, The Journal of clinical and aesthetic dermatology, 9(4), 39-44(2016).

[3] Uter W, Geier J, Contact dermatitis, 72(4), 224 (2015)

[4] Choi S, Park SA, Yoon C, Kim S, J. Korean Soc. Occup. Environ. Hyg., 25(4), 446 (2015)

[5] Lee JW, Chun JY, Kim JH, J. Korean Beauty Society, 20(6), 1068 (2014)

[6] Yang JH, Cho JA, J. Korean Beauty Society, 2(14), 535 (2008)

[7] Arora H, Tosti A, Cosmetics, 4(3), 24 (2017)

[8] Yokota M, Thong HY, Hoffman CA, Maibach HI, Contact dermatitis, 57(4), 277 (2007)

[9] Bernauer U, Coenraads PJ, Degen GH, Dusinska M, et al., Regulatory Toxicology and Pharmacology, 73(3), 658 (2015)

[10] Quach T, Gunier R, Tran A, Behren JV, Billings PAD, et al., American Journal of Public Health, 101(S1), S271-S276(2011).

[11] Byun Y, Ward A, Whiteside S, Food Hydrocolloids, 27, 364 (2012)

[12] Stummer S, Salar-Behzadi S, Unger FM, Oelzant S, Penning M, Viernstein H, Food Research International, 43, 1312 (2010)

[13] Limmatvapirat S, Limmatvapirat C, Puttipipatkhachorn S, Nuntanid J, Luangtana-anan M, Eur. J. Pharm. Biopharm., 67, 690 (2007)

[14] Rubinstein MH, Musikabhumma P, Pharm. Acta. Helv, 53(5), 125 (1978)

[15] Mosmann T, J. Immun. Method, 65, 55 (1983)

[16] Han DG, Noh DY, Shim HE, Jeong SH, ParK SH, Choi HS, Kim DU, Korean Chem. Eng. Res., 56(3), 309 (2018)

[17] Booth DG, Dann SE, Weller MT, Dyes Pigment., 58, 73 (2003)

[18] Allen NS, Polym. Degrad. Stabil., 44, 357 (1994)

[19] Plesters J, Studies in Conservation, 11(2), 62 (1966)

[20] Khairuddin, Pramono E, Utomo SB, Wulandari V, Zahrotul W, Clegg F, Materials Science and Engineering, 107, 01206 (2016)

[21] Soradech S, Limatvapirat S, Luangtana-Anan M, J. Food Eng., 116(2), 572 (2013)