1,2-dichloroethane (1,2-DCE) is a representative industrial chlorinated volatile organic compound (CVOC) making great hazardous to the environment and human health. In this work, LaSrMnCoO6 (LSMC) double perovskite-type materials with high thermal stability and coke resistance in 1,2-DCE oxidation were prepared by a facile sol-gel method. Based on this, a series of CrOx/LaSrMnCoO6 catalysts (Cr/LSMC, CrOx loading = 5 to 20 wt.%) which combine the merits of CrOx (high activity and chlorine tolerance) and LaSrMnCoO6 were synthesized and adopted in deep oxidation of 1,2-DCE for the first time. As expected, obvious synergistic effects between CrOx and LSMC on 1,2-DCE destruction were observed. Amongst, 10 wt% CrOx/LaSrMnCoO6 (10Cr/LSMC) shows the best catalytic activity with 90% of 1,2-DCE destructed at 400 degrees C. Furthermore, the outstanding catalytic durability and water resistance of 10Cr/LSMC in 1,2-DCE oxidation were also demonstrated. In addition to this, the reaction pathway of 1,2-DCE decomposition over Cr/LSMC materials was discussed based on the results of online product analysis. We found that the enhanced catalytic performance of Cr/LSMC materials can be reasonably attributed to their high reducibility, excellent 1,2-DCE adsorption capability, and large amounts of surface active lattice oxygen species. It can be anticipated that the Cr/LSMC catalysts are promising materials for CVOC elimination and the results from this work could also provide some new insights into the design of catalysts for CVOC efficient destruction.