Some large capacity offshore wind turbines are constructed in seismically active areas. The occurrence of soil liquefaction during an earthquake can result in severe failures of the offshore wind turbine. The seismic response of the structure and the failure mechanism of the soil-structure interactions are necessary to investigate. In this study, the seismic response of an innovative hybrid monopile foundation is investigated through a series of centrifuge tests. The seismic performance of the combined system of the superstructure, foundation, and soil are demonstrated. Five hybrid foundation models are tested by considering the influence of the foundation thicknesses and diameters, and a monopile foundation is tested for comparison. Centrifuge test results reveal that the hybrid monopile foundation is effective in reducing the lateral displacement during the shaking. In the saturated condition, soil keeps its strength and stiffness beneath and adjacent to the foundation. The hybrid foundation system tends to settle more due to the larger shear stress caused by the soil structure interactions. Influences of the wheel specifications are illustrated. The foundations with larger thicknesses lead to smaller lateral displacements and lower tendencies of liquefaction, but the settlements are intensified. The larger diameter foundation provides a longer drainage path for the excess pore water pressure. With a similar weight, the structure settles less during the earthquake.