A recently developed equation of state-excess Gibbs free energy (EOS/G(E)) model with the LCVM (linear combination of Vidal and Michelsen) mixing rule, capable of successful VLE prediction in asymmetric systems is applied to the prediction of solubilities of alkenes, ethers, acids, alcohols, and esters in supercritical carbon dioxide. Considering the experimental uncertainties, excellent correlation of binary data and satisfactory prediction of ternary and multicomponent equilibria are obtained in most cases over a wide range of temperature, pressure, and system asymmetry. These promising results render the LCVM model a useful tool for the preliminary design of processes involving mixtures with organic compounds and supercritical carbon dioxide.