In recent decades, gas hydrates have received significant attention due to their potential roles in energy and environmental applications. The formation of gas hydrates involves a process to assemble variously shaped frameworks made of hydrogen bonded networks of H2O molecules, and thus ionic species, such as Na+, K+, Mg2+, Ca2+, Cl-, SO42-, etc., can be excluded from the solid gas hydrate phase. Therefore, gas hydrates can potentially be utilized in desalination technology. For potential application to a hydrate-based desalination (HBD) process, three cyclic compounds, cyclopentane (CP), cyclopentanone (CP-one), and cyclopentanol (CP-ol), were selected, focusing on a comparison of thermodynamic and kinetic effects. From the thermodynamic view, the study confirmed that the hydrate formation was favorable in the order of CP, CP-one, and CP-ol in the presence of CH4 or CO2. For the kinetic comparison, however, CP-ol and CP-one showed a relatively shorter induction time than CP. The conversion yield of CO2 hydrate of CP-one was more than double those of CP and CP-ol hydrates, which is ascribed to the unique hydration of the ketone during the hydrate formation. The findings suggest that CP-one could be a promising candidate for the HBD process.