Base-on the excellent optoelectronic properties, perovskite CsPbBr3 quantum dots (QDs) have been used on perovskite solar cells and LED devices, but little research has been focused on photochemical CO2 reduction due to their poor moisture stability. Coincidentally, metal-organic frameworks (MOFs) materials have received tremendous attention for sustainable clean energy and environmental remediation. However, the design of excellent performed MOFs is still indispensable. Therefore, the CsPbBr3 QDs/UiO-66(NH2) nanocomposites that combine the advantages of CsPbBr3 QDs and UiO-66(NH2) have been successfully designed and fabricated for the first time. Then we employ the nanocomposites as photocatalysts to convert CO2 to chemical fuels in nonaqueous media. The resultant nanocomposites exhibit significantly improved photocatalytic activity for CO2 reduction. When CsPbBr3 QDs content is 15 wt%, the amount of CO can reach 98.57 mol.g(-1) . The remarkable photocatalytic performance could be ascribed to the improved electron extraction and transfer between UiO66(NH2) and CsPbBr3 QDs, large accessible specific surface area and enhanced visible light absorption capacity. Moreover, the nanojunction shows excellent reusability for photocatalytic CO2 reduction. This work might supply new pathway to utilize halide perovskite QDs/MOF nanocomposite in energy conversion and environmental remediation.