In the reported work, we have approached the interaction of the amino acids onto the antimonene (Sb) monolayer by using density functional theory (DFT). Here, we have considered glycine (Gly), glutamic (Glu), histidine (HIE/His) and phenylalanine (Phe) biomolecules for interaction. The structural, electronic and optical properties have been investigated to understand the behavior. The adsorption of the biomolecules on Sb monolayer show the physisorption process. The adsorption energy of the phenylalanine (Phe) biomolecules is the most favorable. The optical absorption peaks of systems come in the near visible region. The studies conclude that Sb monolayer is useful for the bio-integrated electronics based devices.