A new tripodal hexadentate ligand of tris[6-(1H-pyrazol-1-yl)pyridin-2-yl]methanol (tppm) was synthesized and explored for constructing the trigonal-prismatic cobalt(II) complex [Co(tppm)]-[ClO4](2)center dot 2CH(3)CN center dot H2O (1). Magnetic study showed that 1 exhibited large uniaxial magnetic anisotropy with a zero-field-splitting parameter of -80.7 cm(-1) and typical single molecule-magnet behavior.