Journal of the American Chemical Society, Vol.116, No.12, 5523-5524, 1994
Role of the CC-1065 and Duocarmycin N-2 Substituent - Validation of a Direct Relationship Between Solvolysis Chemical-Stability and in-Vitro Biological Potency
Keywords:ENHANCED FUNCTIONAL ANALOGS;(+)-CC-1065 DNA ALKYLATION;NONCOVALENT BINDING SELECTIVITY;ANTITUMOR ANTIBIOTICS;1;2;9;9A-TETRAHYDROCYCLOPROPA(C)BENZ(E)INDOL-4-ONE CBI;ELECTROPHILE REACTIVITY;PYRINDAMYCIN-A;SUBUNIT;STREPTOMYCES;AGENTS