An integrated analysis of laser induced breakdown (LIB) and the associated micro-cavitation in a water-like bio-tissue is developed in this study. With this integrated analysis using minimum experimentally fitted parameters, threshold energies of LIB in bio-tissue under different numerical apertures of the focusing lenses can be determined, which provides similar values as the corresponding experimental measurements. The integrated analysis can also determine the electron temperature and number density when LIB is triggered, which also fall in the same order as the corresponding experimental measurements. In addition, the rapid size increment of plasma plume through laser supported detonation wave during a LIB can be observed with the integrated analysis. The developed integrated analysis becomes unstable when strong pressure wave presents due to strong heating and the following rapid expansion of the bio-tissue under higher input laser energy (compared with the threshold energy of LIB). Therefore, for simulating high energy LIB and the following micro-cavitation in a bio-tissue, a more advanced numerical scheme that can better capture the propagation of pressure wave will be required in the future. (C) 2018 Elsevier Ltd. All rights reserved.