To increase the contribution and reliability of computational fluid dynamics efforts in design process of industrial equipments, it is necessary to quantify the effects of uncertainties on the system performance. Due to exponentially increment of the computational cost with number of uncertain variables for uncertainty quantification using classical polynomial chaos expansion methodology, reducing the required number of samples for uncertainty quantification is a real engineering challenge. In this paper, the proper orthogonal decomposition method based on the multifidelity approach is combined with the full and sparse polynomial chaos expansions for efficient uncertainty quantification of complex heat transfer problems with large number of random variables. The conjugate conduction heat transfer in NASA OX cooled gas turbine blade with geometrical uncertainties and the convective heat transfer in ribbed passage with the stochastic wall heat flux boundary condition are considered as the test cases. Results of uncertainty quantification analysis in both test cases showed that proposed multi-fidelity approaches are able to produce the statistical quantities with much lower computational cost compare to the classical regression-based polynomial chaos method. It is shown that the combination of the proper orthogonal decomposition with the sparse polynomial chaos gives a computational gain at least 2 times greater than combination of the proper orthogonal decomposition with the full polynomial chaos expansion. (C) 2018 Elsevier Ltd. All rights reserved.