The crucial problems for the catalysts of CO2 methanation are the low activity at low temperature and deactivation caused by metal sintering. In order to overcome the problems or to improve the shortages, a new scheme has been put forward by loading LaNi1-xMoxO3 with perovskite-type structure on SiO2. After reduction, Ni nanoparticles, MoOx and La2O3 would be all stay together and highly dispersed on SiO2 (Ni/MoOx-La2O3/SiO2). The techniques of BET, XRD, H-2-TPR, HRTEM, ICP, H-2 chemisorption and XPS were used to characterize the prepared samples. Through effectively combining MoOx which is active for the reaction of reverse water gas shift and Ni which can catalyze CO methanation, the resultant Ni/MoOx-La2O3/SiO2 catalyst exhibited pretty good performance for CO2 methanation, especially showing very good resistance to metal sintering. Ni-La2O3/SiO2 catalyst without adding Mo was investigated for comparison. Since many metallic ions can enter into the lattice of a perovskite-type oxide, therefore, many combined catalysts for sequential reactions may be designed via this scheme. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.