Hypothesis: In this manuscript we examine the stability of an evaporating-unbounded axisymmetric liquid bridge confined between parallel-planar similar or chemically different substrates using both theory and experiments. With a quasistatic assumption we use hydrostatics to estimate the minimum stable volume V-min via the Young-Laplace equation for Bond numbers 0 <= Bo <= 1, and top/bottom wall contact angles 5 degrees < theta < 175 degrees although the primary focus is on wetting and partial wetting fluids. Solving the Young-Laplace equation requires knowledge of appropriate capillary pressure values, which appear as a constant, and may not provide unique solution. To examine uniqueness of numerical solutions and volume minima determined from the Young-Laplace equation for unbounded-axisymmetric liquid bridges we analyzed capillary pressure for large and small liquid volume-asymptotic limits at zero Bond number. Experiments: Experiments were performed to compare with the volume minima calculations for Bond numbers 0.04 <= Bo <= 0.65. Three substrates of varying surface energy were used, with purified water as the primary liquid. Volume estimates and contact angle data were extracted via image analysis and evaporation rates measured from this data are reported. Findings: Volume minima were in the range 0.1 < V-min < 20 mu l depending on Bond number. There was good agreement when comparing predicted volume minima and those determined from experiments for the range of parameters studied. (C) 2018 Elsevier Inc. All rights reserved.