A novel and simple method was developed to quickly pattern and transfer electrodes with nanostructures for fabricating flexible electronic skin (E-skin). A nano/micro-structure embedded Cu electrode can be fabricated from a solution process-based electroless deposition (ELD) on a frosted plastic substrate and subsequently flipped over with an adhesive tape. The fine nano/microstructures on the Cu layer benefit the pressure-electric response of the pressure sensor, demonstrated a high sensitivity: 2.22 kPa(-1). This fabricated flexible E-skin can be used for monitoring human physiological signals, such as wrist pulse and thumb bending. This fabrication method is an economical tool for fast prototyping cost-effective wearable electronics for the detection and prediction of diseases. It offers opportunity for researchers from resource-limited laboratories to work on miniaturized wearable devices. (C) 2018 Elsevier Inc. All rights reserved.