When carrier systems like solid lipid nanoparticles (SLN) are added to a protein rich food matrix adsorption of protein to the particles alters the surface properties of SLN which in turn can alter the properties of the whole system. Thus, the effect of the SLN composition on the protein adlayer (protein corona) is important to understand. The adsorption of beta-lactoglobulin (beta LG) to unloaded SLN and SLN loaded with ferulic acid or tocopherol was studied at pH 5.7 and particle:protein ratios of 2:1 to 10:1 (w/w) by centrifugation, AF4 and ultrafiltration (UF). Up to 10% of the beta LG was strongly bound to SLN whereas 40-80% of the beta LG formed a loose adlayer. The amount of bound beta LG was increased by the presence of tocopherol and decreased by the presence of ferulic acid. The adsorbed protein layer thus depends on SLN characteristics governed by encapsulated compounds.