The aim of this study was to evaluate the efficiency of methyl acetate as a solvent in the pressurized liquid extraction (PLE) of crambe seed oil. The extractions were conducted in an experimental apparatus operated in semi-continuous mode and the effects of solvent flow and temperature on the yield and quality of the oil obtained were evaluated. The results were compared with those for oil obtained from Soxhlet extraction method and a commercial sample. An increase in the solvent flow and in the temperature promoted a greater removal of oil from seeds under pressurized conditions and a yield of 49.1% was achieved. The fatty acids composition was not influenced by the methods evaluated and the oil convertibility decreased with the use of higher temperatures. The oil extracted by PLE presented higher concentrations of phytosterols and tocopherols, as well as high resistance to oxidation compared to the oil from Soxhlet method.