This study aimed to evaluate the effects of pressure (150, 175 and 200 bar), temperature (40, 50 and 60 degrees C) and CO2 flow rate (2, 3 and 4 mL min^-1) on the yield of supercritical extraction of Eugenia involucrata leaves. The extracts were characterized for alpha-tocopherol content and antioxidant activity in comparison to the n-hexane extract obtained by the Soxhlet technique. The greatest yield, 1.73 wt%, was obtained by the highest density and using the highest CO2 flow rate (200 bar, 40 degrees C and 4 mL min^-1). Variation in the experimental conditions resulted in an increase of up to 165% in the alpha-tocopherol yield, with a possible yield of up to 68.27 mgalpha-tocopherol 100gleaves ^-1. The antioxidant activity determined by the DPPH method showed a high correlation with the content of alpha-tocopherol, with a maximum of 95.35 mu molTrolox gextract ^-1. The experimental kinetic curves were satisfactorily described by Sovova mathematical model.