Classical strong metal support interactions (SMSI), which play a crucial role in the preparation of supported metal nanoparticle catalysts, is one of the most important concepts in heterogeneous catalysis. The conventional wisdom for construction of classical SMSI involves in redox treatments at high-temperatures by molecular oxygen or hydrogen, sometimes causing sintered metal nanoparticles. before SMSI formation. Herein, we report that the aforementioned issue can be effectively avoided by a wet chemistry methodology. As a typical example, we demonstrate a new concept of wet-chemistry SMSI (wcSMSI) that can be constructed on titania-supported Au nanoparticles (Au/TiO2-wcSMSI), where the key is to employ a redox interaction between Au delta+ and Ti3+ precursors in aqueous solution. The wcSMSI is evidenced by covering Au nanoparticles with the TiOx overlayer, electronic interaction between Au and TiO2, and suppression of CO adsorption on Au nanoparticles. Owing to the wcSMSI, the Au-TiOx interface with an improved redox property is favorable for oxygen activation, accelerating CO oxidation. In addition, the oxide overlayer efficiently stabilizes the Au nanoparticles, achieving sinter-resistant Au/TiO2-wcSMSI catalyst in CO oxidation.