Journal of the American Chemical Society, Vol.141, No.1, 154-158, 2019
Concise Syntheses of Delta(12)-Prostaglandin J Natural Products via Stereoretentive Metathesis
Delta(12)-Prostaglandin J family is recently discovered and has potent anticancer activity. Concise syntheses of four Delta(12)-prostaglandin J natural products (7-8 steps in the longest linear sequences) are reported, enabled by convergent stereoretentive cross-metathesis. Exceptional control of alkene geometry was achieved through stereoretention.