Kirsten Rat Sarcoma (KRAS) and protein tumor suppressor (p53) are two biomarkers used to establish the correct diagnostic of cancer and also the personalized treatment. This paper proposed 2,6-bis((E)-2-(furan-2-yl)vinyl)-4-(4,6,8-trimethylazulen-1-yl)pyridine as nanostructured material for the design of stochastic sensors for fast recognition of p53 and KRAS in whole blood samples. The proposed stochastic sensors recognized p53 and KRAS in whole blood samples, with high sensitivities, at very low concentrations (fg/mL). The recovery tests performed proved that p53 and KRAS were determined in whole blood samples with average recoveries higher than 98.00% and RSD (%) values less than 0.20%, when they are in very small amounts. No sample treatment was required for whole blood samples collected from the patients. (C) 2019 The Electrochemical Society.