Over the past few decades, fabrication of optimal nanostructures for detecting specific bio-entities remained an active area of research. It is well-known that the structure and the plasmonic properties of noble metal nanoparticles can be customized for specific applications such as biosensing, diagnosis, imaging, etc. by tuning the size and shape of the nanoparticles. Thus, by using the plasmonic property of noble metals, the detection at the nano-scale is possible by monitoring the shift of Localized Surface Plasmon Resonance (LSPR) band with respect to the changes in the dielectric constant of the surrounding medium. The present study is aimed to the evaluation of the quality and performance of two nano plasmonic platforms for detection and capture of exosomes. (C) The Author(s) 2018. Published by ECS.