Polylactide (PLA) stereocomplexes (SCs) were prepared from low molecular weight PLLA and PDLA with terminal carboxyl groups in the presence and in the absence of calcium oxide being a donor of metal ions. Only the stereocomplexation performed in the presence of metal ions causing PLA macromolecules preorganization resulted in the SC formation in a form of spherical microparticles (microspheres). Hydrolyses of microspheres containing CaO and the SC without CaO were performed in a phosphate buffer pH=7.4 at temperatures 37 and 50 degrees C. The rate of hydrolytic degradation of SCs was studied and compared to find the effect of the metal ions presence. The results of the hydrolysis were analyzed by the observation of polymer samples using scanning electron microscopy and infrared spectroscopy, also by differential scanning calorimetry measurements.