The influence of different isomalt particle morphologies on dry granule and tablet properties was investigated. Primary crystals, milled particles and agglomerates were tableted after roll compaction/dry granulation and compared to the directly compressed powders. Afterwards, the changes in tabletability were evaluated. Particle size distribution and specific surface area were measured for powders and granules. The influence of different specific compaction forces on granule and tablet properties was investigated. Milled and agglomerated isomalt resulted in products with adequate quality attributes. The agglomerates led to sufficient particle size enlargement even at low specific compaction forces. For all morphologies, the specific surface area increased during granulation, but to a different degree. Production under high compaction force or tableting pressure induced the destruction of the starting agglomerates and therefore product characteristics were similar to that of products produced from milled raw material. High tableting pressure induced an overpressing of isomalt tablets in particular in case of agglomerates. The investigated primary crystals were neither suitable for direct compression nor roll compaction/dry granulation. Milling effects predominated the compaction and therefore granules were smaller than the starting material. In summary, the milled and agglomerated isomalt performed as sufficient filler/binder in roll compaction/dry granulation. (C) 2018 Elsevier B.V. All rights reserved.