Batch adsorption of triglyceride (TG) from the human blood serum was investigated using cinnamon as a novel serum-contact biosorbent. Important factors affecting the adsorption including; temperature, contact time, stirring rate, adsorbent dose and, particle size were investigated through optimization using central composite design methodology. SEM and FTIR analyses were employed to characterize the adsorbent. The Langmuir, Freundlich, Temkin, and Dubinin-Radushkevitch isotherm models were employed to study the adsorption equilibria and the Langmuir and D-R models showed better agreement with the experimental data. The maximal TG adsorption and removal percentage values were determined as 18.12 mg/g and 75.16%, respectively. The pseudo-first order, pseudo-second order, intra-particle diffusion, and Elovich models were used to describe the adsorption kinetic and the pseudo-second order model better represented the data. Gibbs free energy and enthalpy changes were determined as -22.64 and 20.21 kJ/mol, respectively. Optimization results demonstrated that the optimal conditions for the adsorption were the adsorbent dose of 0.94 g, milling time of 9.19 min, stirring rate of 255 rpm, temperature of 23.41 degrees C and, contact time of 35 min which resulted in the optimal TG removal (88.2%). Based on the results, cinnamon is an efficient triglyceride reducer for possible application in extracorporeal blood perfusion.