Acetone-butanol-ethanol can be widely obtained from biomass fermentation broth. In the article, the catalytic deoxygenation of the acetone-butanol-ethanol mixture are studied to upgrade the ABE to chemicals such as alkene and benzene derivate in a continuous fixed bed. The experiment was run at room pressure and in the temperature range of 240-320 degrees C using inert N-2 or H-2 as carrier gases as well as different WHSV to observe the effect on the deoxygenation products distribution. The results showed that ketones, long chain alkenes, cycloolefine (C-9-C-13, 17.44%) and benzene derivate (C-7-C-15, 15.77%) were obtained as the main products by catalytic deoxygenation of acetone-butanol-ethanol. Compared with single support catalysts Ni-Sn/MCM-41 and Ni-Sn/gamma-Al2O3, the mixed support catalysts Ni-Sn/MCM-41+gamma-Al2O3 possessed moderate BET surface, acidic sites and good resistant ability to carbon deposition, which promoted the formation of benzene derivate,2-heptanone (8.32%) and 5-undecene (11.84%). The study supplies the data for producing long chain alkene, cycloolefine and benzene derivate from short chain precursors via combining the bio-technology and chemical conversion. (C) 2018 Elsevier Ltd. All rights reserved.