In this research, a drug-imprinted polymer upon polymerization was done with 3-allyloxy-1, 2-propanediol as a functional monomer, N-vinyl caprolactam as a thermosensitive monomer, N, N '-methylenebisacrylamide, as a cross-linker agent, sumatriptan succinate as a template and azobis isobutyronitrile as an initiator. The engineered drug-imprinted polymer was evaluated by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The drug-imprinted polymer sorbent operated selective for sumatriptan succinate. This study examines the determination of sumatriptan succinate in human urine and plasma samples by high-performance liquid chromatography with great results.