Dissolving Microneedle Systems for the Oral Mucosal Delivery of Triamcinolone Acetonide to Treat Aphthous Stomatitis

Hye-Seung Seon-Woo; Hee Joo Kim; Joo Young Roh; Jung-Hwan Park

Macromolecular Research, Vol.27, No.3, 282-289, March, 2019

DOI10.1007/s13233-019-7031-6 Export Citation

Dissolving Microneedle Systems for the Oral Mucosal Delivery of Triamcinolone Acetonide to Treat Aphthous Stomatitis

Hye-Seung Seon-Woo, Hee Joo Kim¹, Joo Young Roh^{1, †}, and Jung-Hwan Park^†

Department of BioNano Technology and Gachon BioNano Research Institute, Gachon University, Seongnam, Gyeonggi 13120, Korea
¹Department of Dermatology, Gil Medical Center, Gachon University, College of Medicine, Incheon 21565, Korea

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A microneedle (MN) oral mucosal patch system was prepared to increase its adhesive strength, to improve the delivery of triamcinolone acetonide (TA) into the mucosa, and to protect the adhesive layer from mouth movement and saliva. The MN oral mucosal patch system consists of an adhesive layer containing TA and a backing layer. The adhesive layer consists of a base with a thickness of 50 μm, 300 μm long MNs, and 18% TA. After patches were attached to the tape-stripped porcine skin for a predetermined period of time, the adhesion of the patches was observed. TA was extracted from the skin, and the amount of TA was measured using high-performance chromatography. When the adhesive layer was applied for 10 s, the adhesive strength was 1.69 N mm/cm2 with microneedles and 0.41 N mm/cm2 without microneedles. An oral mucosal patch with MNs (TA MN-AL) delivered 42% more TA into the skin than an oral mucosal patch without MNs (TA AL). Also, as attachment time increased, the amount of TA delivered was significantly greater using a TA MN-AL compared to a TA AL. The addition of MNs can increase the adhesion of the oral mucosal patch to the mucosa and thus improve the efficiency of drug delivery.

Keywords:oral mucosal patch;microneedles;backing layer;adhesive strength;drug delivery;aphthous stomatitis;triamcinolone acetonide

[References]

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Shemer A, Amichai B, Trau H, Nathansohn N, Mizrahi B, Domb AJ, Drugs R. D., 9, 29 (2008)
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Duchene D, Ponchel G, Eur. J. Pharm. Biopharm., 44, 15 (1997)
Jeong HR, Lee HS, Choi IJ, Park JH, J. Drug Target., 25, 29 (2017)
Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Kerr AR, Lockhart PB, Patton LL, Porter S, Thornhill MH, Adv. Drug Deliv. Rev., 64, 16 (2012)
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[2] Vincent SD, Lilly GE, Oral Surg. Oral Med. Oral Pathol., 74, 79 (1992)

[3] Scully C, Gorsky M, Lozada-Nur F, J. Am. Dent. Assoc., 134, 200 (2003)

[4] Akintoye SO, Greenberg MS, Dent. Clin., 58, 281 (2014)

[5] Scully C, Porter S, J. Oral Pathol. Med., 18, 21 (2006)

[6] Fani MM, Ebrahimi H, Pourshahidi S, Aflaki E, Sarvestani SS, Iran. Red. Crescent. Med. J., 14, 75 (2012)

[7] Miles DA, Bricker SL, Razmus TF, Potter RH, Oral Surg. Oral Med. Oral Pathol., 75, 397 (1993)

[8] Donnelly RF, Singh TRR, Woolfson AD, Drug Deliv., 17, 187 (2010)

[9] Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, Pewin W, Frew PM, Yu T, Thornburg NJ, Lancet, 390, 649 (2017)

[10] Marshall S, Sahm LJ, Moore AC, Vaccine, 34, 723 (2016)

[11] Jeong HR, Kim JY, Kim SN, Park JH, Eur. J. Pharm. Biopharm., 127, 237 (2018)

[12] Lee HS, Ryu HR, Roh JY, Park JH, Pharm. Res., 34, 101 (2017)

[13] Shemer A, Amichai B, Trau H, Nathansohn N, Mizrahi B, Domb AJ, Drugs R. D., 9, 29 (2008)

[14] Mumtaz AM, Ch'ng HS, Int. J. Pharm., 121, 129 (1995)

[15] Reddy PC, Chaitanya K, Rao YM, Daru J. Pharm. Sci., 19, 385 (2011)

[16] Serpe L, Jain A, de Macedo CG, Volpato MC, Groppo FC, Gill HS, Franz-Montan M, Eur. J. Pharm. Sci., 93, 215 (2016)

[17] Dickel H, Goulioumis A, Gambichler T, Fluhr JW, Kamphowe J, Altmeyer P, Kuss O, in Agache’s Measuring the Skin, p289 2017.

[18] Fahs A, Brogly M, Bistac S, Schmitt M, Carbohydr. Polym., 80, 105 (2010)

[19] Chun MK, Kwak BT, Choi HK, Arch. Pharm. Res., 26, 973 (2003)

[20] Prajapati V, Bansal M, Sharma PK, Int. J. PharmTech. Res., 4, 582 (2012)

[21] Duchene D, Ponchel G, Eur. J. Pharm. Biopharm., 44, 15 (1997)

[22] Jeong HR, Lee HS, Choi IJ, Park JH, J. Drug Target., 25, 29 (2017)

[23] Hearnden V, Sankar V, Hull K, Juras DV, Greenberg M, Kerr AR, Lockhart PB, Patton LL, Porter S, Thornhill MH, Adv. Drug Deliv. Rev., 64, 16 (2012)

[24] Srinivasa P, Ramesh M, Tharanathan R, Food Hydrocolloids, 21, 1113 (2007)

[25] Galey WR, Lonsdale H, Nacht S, J. Invest. Dermatol., 67, 713 (1976)