Journal of the American Chemical Society, Vol.117, No.8, 2357-2358, 1995
Kinetic Evidence Based on Solvent Isotope Effects for the Nonexistence of a Proton-Transfer Process in Reactions Catalyzed by a Hammerhead Ribozyme - Implication to the Double-Metal-Ion Mechanism of Catalysis
Keywords:MARGINALLY STABLE INTERMEDIATE;CLEAVAGE REACTION;RNA HYDROLYSIS;SELF-CLEAVAGE;PHOSPHOROTHIOATE;PHOSPHATE;ABINITIO;METHANOLYSIS;INVENTORY;STEP