Chiral semiconductor nanorods and their heterostructures have attracted intense attention. In this work, it was shown that chiral amino acids on CdSe@CdS semiconductor nanorods (SNR) displayed circular dichroism bands (CD, 200-480 nm). Longer SNRs were found to induce stronger CD intensities, while an increase in the SNR diameter led to a clear CD band redshift. Multi-site post-growth of platinum (Pt) and gold (Au) further enhanced the CD intensity and induced CD band transitions. Electromagnetic calculations revealed that the metal post growth gave rise to a strong electromagnetic field enhancement, with Pt inducing a stronger enhancement than Au. The optimized chiral multi-sites platinum on SNR displayed higher photocatalytic activities manifested that the deposited metal endowed energy transfer and enhanced the separation of photo-excited electrons and holes. These findings demonstrated that the multi-sites deposited metal provided a method to produce strong optical activity of nanostructures by adjusting the morphology of the semiconductor nanorod.