In this study, a 200-day deca-brominated diphenyl ether (deca-BDE) degradation activity experiment was carried out, using consumer-use curtain material as the substrate. During the degradation process, polybrominated diphenyl ether (PBDE) products with fewer bromine atoms were gradually generated by the debromination of deca-BDE. The influences of temperature, initial substrate dosing mass, and pH were also investigated. Interestingly, thermophilic conditions proved more beneficial for deca-BDE degradation than mesophilic conditions. The results also demonstrate that the debromination rate increased with the initial deca-BDE dosing mass, and that pH 7 was the most suitable for the reaction.