Nanotherapies combined with stimuli-triggered activated agents have become attractive ways to traditional chemotherapy. The Fe3O4 nanoparticles was employed as the core coated firstly with hydrogels of dually loaded both doxorubicin and hematoporphyrin monomethyl ether. Then, the folic acid was grafted onto the surface of the composites to construct a laser-sensitized magnetic nanoparticles (LMNs), followed by these LMNs being loaded into BC membrane. On the 14th day after treatment, tumor growth inhibition (TGI) was evaluated to 80.38% under the target system. When delivered transdermally under a magnetic field and laser, the synthesized BC/LMNs could offer solutions to challenge in breast cancer treatment, including the limited penetration depth, which could facilitate the bypassing of the stratum corneum barrier and enhance transdermal drug delivery.