Antioxidants play a crucial role in the protection and maintenance of health and are also integral ingredients in beauty products. The active antioxidants possess numerous outstanding features that are useful for cosmetic formulations. However, there are many problems related to their instability and insolubility that have been restricting their practical applications and which has led to the advent of core-shell materials, mainly lipid nanoparticles and nanoemulsions as one of the most effective solutions to protect those antioxidants and broaden their applicability to cosmetic products. Unfortunately, the production and application of core-shell materials in the cosmetics industry face many other challenges as well. Here, some of the main problems relating to the loss of the protective function as well as the limitations of material's preparation techniques are reviewed and discussed in depth. Simultaneously, development strategies for resolving the corresponding problems are underlined. These strategies have been meeting the development needs of the cosmetics industry in the present and will continue to do so for at least the near future. In addition, strategies for stimulating the progress of the cosmetics industry are anticipated.